Cryo-electron microscopy is becoming mainstream for studying molecular details such as the architecture of cells, viruses as well as nucleic acids, small molecules, and protein assemblies. Recent developments in microscope design and imaging hardware, automation, and advances in camera technology have greatly advanced the effectiveness of cryo-EM methods. We are now living in the area of the “Cryo-EM resolution revolution”. Our facility is equipped with a Thermo Scientific Arctica, which is a 200kV FEG transmission electron microscope used for delivering high-resolution 3D characterization of biological samples.